Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Proteomics. 2013 Feb;13(3-4):504-11. doi: 10.1002/pmic.201200333.
N-linked glycoproteins play important roles in biological processes, including cell-to-cell recognition, growth, differentiation, and programmed cell death. Specific N-linked glycoprotein changes are associated with disease progression and identification of these N-linked glycoproteins has potential for use in disease diagnosis, prognosis, and prediction of treatments. In this review, we summarize common strategies for N-linked glycoprotein characterization and applications of these strategies to identification of glycoprotein changes associated with disease states. We also review the N-linked glycoproteins altered in diseases such as breast cancer, lung cancer, and prostate cancer. Although assays for these glycoproteins have potential clinical utility, research is needed to translate these glycoproteins to clinical biomarkers.
N-连接糖蛋白在生物过程中发挥着重要作用，包括细胞间识别、生长、分化和程序性细胞死亡。特定的 N-连接糖蛋白变化与疾病进展有关，这些 N-连接糖蛋白的鉴定具有用于疾病诊断、预后和治疗预测的潜力。在这篇综述中，我们总结了 N-连接糖蛋白特征描述的常用策略以及这些策略在鉴定与疾病状态相关的糖蛋白变化中的应用。我们还综述了乳腺癌、肺癌和前列腺癌等疾病中改变的 N-连接糖蛋白。虽然这些糖蛋白的检测方法具有潜在的临床应用价值，但需要进行研究将这些糖蛋白转化为临床生物标志物。
