Francis K T
Psychosom Med. 1979 Dec;41(8):617-28. doi: 10.1097/00006842-197912000-00003.
Correlations between serum uric acid, cortisol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and psychometric indices of stress--namely, anxiety, hostility, and depression--were investigated in 20 students over a 2 1/2 month academic quarter. There were three peak periods of stress, with two occurring during midterm and final exams. The observed changes in serum cortisol were highly correlated with changes in anxiety and depression. Serum uric acid was significantly depressed during the first half of the quarter, but returned to control levels after midterm exams. Serum cholesterol and the LDL cholesterol subfraction were significantly elevated above control levels and remained elevated throughout the quarter after the first day of classes. Absolute levels of HDL cholesterol varied little throughout the quarter, however, the ratio of HDL cholesterol/total cholesterol was significantly depressed twice in the quarter, each time following approximately 10 days after the peak period of stress.
在20名学生的两个半月的学术季度中，研究了血清尿酸、皮质醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇与压力心理测量指标（即焦虑、敌意和抑郁）之间的相关性。有三个压力高峰期，其中两个发生在期中考试和期末考试期间。观察到的血清皮质醇变化与焦虑和抑郁的变化高度相关。血清尿酸在季度上半段显著降低，但在期中考试后恢复到对照水平。血清胆固醇和LDL胆固醇亚组分显著高于对照水平，并在课程开始后的整个季度中保持升高。HDL胆固醇的绝对水平在整个季度中变化不大，然而，HDL胆固醇/总胆固醇的比率在季度中两次显著降低，每次都在压力高峰期后的大约10天之后。
