Gvozdjáková Anna, Mravec Boris, Kucharská Jarmila, Lackovičová Lubica, Ondičová Katarína, Tkačov Martin, Singh Ram B
Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Gen Physiol Biophys. 2012 Dec;31(4):469-72. doi: 10.4149/gpb_2012_052.
Brain coenzyme Q10 (CoQ10) concentration can influence the activity of several brain regions, including those which participate in the regulation of cardiovascular circadian rhythms, food intake, neuroendocrine stress response, activity and sleep regulation. However, the effect of supplemented ubiquinol (reduced CoQ) into brain regions is not known. This study determined baseline levels of ubiquinone (oxidized CoQ) in various rat brain regions and proved the bioavailability of the liposomal ubiquinol to selected brain regions after its administration into right brain ventricle. Our data indicate that administration of ubiquinol may create the basis for modulation of neuronal activities in specific brain regions.
脑内辅酶Q10（CoQ10）浓度可影响多个脑区的活性，包括参与心血管昼夜节律、食物摄入、神经内分泌应激反应、活动及睡眠调节的脑区。然而，向脑区补充泛醇（还原型CoQ）的效果尚不清楚。本研究测定了各种大鼠脑区中泛醌（氧化型CoQ）的基线水平，并证实了脂质体泛醇经右脑室内给药后对选定脑区的生物利用度。我们的数据表明，泛醇给药可能为调节特定脑区的神经元活动奠定基础。
