Department of Neonatology, Center for Child Health, Sir Ganga Ram Hospital, New Delhi.
Indian Pediatr. 2013 Jun 8;50(6):573-7. doi: 10.1007/s13312-013-0170-5. Epub 2012 Nov 5.
To evaluate growth and neurodevelopmental outcome of very low birth weight infants (VLBW) and compare with term normal birth weight infants (NBW) till 12 months corrected age.
A prospective cohort study.
Tertiary care neonatal unit in northern India.
37 VLBW infants and 35 NBW infants born between January 2007 and December 2007.
Anthropometric measurements were recorded and Z-scores were computed serially at birth, discharge, 40 weeks post menstrual age (PMA), and at 1, 3, 6 and 12 months of corrected age. Developmental quotient (DQ) at 12 months corrected age was assessed.
Z-scores for weight, length and head circumference (HC) at birth were -1.21(±0.92), -0.98(±1.32) and -0.70(±1.14), respectively for VLBW infants and -0.37(±0.72), -0.11(±0.96) and 0.05(±0.73) respectively for NBW infants. VLBW infants had a significant drop in all Z-scores by discharge (P<0.001). There was a catch up to birth scores by 12 month age. VLBW infants had significantly lower Z-scores for weight, length and HC at one year corrected age as compared to NBW infants (P =0.01, 0.04 and 0.001, respectively). DQ at 12 months was significantly lower in VLBW infants (91.5+7.8) than NBW infants (97.5±5.3) (P <0.001). DQ of small for gestational age (SGA) and appropriate for gestational age (AGA) VLBW infants was comparable.
VLBW infants falter in their growth during NICU stay with a catch-up later during infancy. In comparison to NBW infants, they continue to lag in their physical growth and neurodevelopment at 1 year of corrected age.
评估极低出生体重儿（VLBW）的生长和神经发育结局，并与同期足月正常出生体重儿（NBW）进行比较，随访至 12 个月校正年龄。
前瞻性队列研究。
印度北部的三级新生儿重症监护病房。
2007 年 1 月至 2007 年 12 月出生的 37 名 VLBW 婴儿和 35 名 NBW 婴儿。
出生时、出院时、40 周月经龄（PMA）、1 个月、3 个月、6 个月和 12 个月时连续记录体格测量值并计算 Z 评分。在 12 个月校正年龄时评估发育商（DQ）。
VLBW 婴儿出生时体重、身长和头围（HC）的 Z 评分分别为-1.21（±0.92）、-0.98（±1.32）和-0.70（±1.14），NBW 婴儿分别为-0.37（±0.72）、-0.11（±0.96）和 0.05（±0.73）。VLBW 婴儿在出院时所有 Z 评分均显著下降（P<0.001）。到 12 月龄时，Z 评分恢复到出生时水平。与 NBW 婴儿相比，VLBW 婴儿在 1 岁校正年龄时体重、身长和 HC 的 Z 评分显著较低（P=0.01、0.04 和 0.001）。VLBW 婴儿的发育商（DQ）为 91.5+7.8，明显低于 NBW 婴儿的 97.5±5.3（P<0.001）。小于胎龄儿（SGA）和适于胎龄儿（AGA）VLBW 婴儿的 DQ 相当。
VLBW 婴儿在新生儿重症监护病房（NICU）期间的生长发育迟缓，在婴儿期后期逐渐赶上。与 NBW 婴儿相比，VLBW 婴儿在 1 岁校正年龄时的体格生长和神经发育仍明显落后。
