基于 BODIPY 的试剂在水溶液中对生物硫醇的生色和荧光传感。
Chromogenic and fluorogenic sensing of biological thiols in aqueous solutions using BODIPY-based reagents.
机构信息
UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey.
出版信息
Org Lett. 2013 Jan 4;15(1):216-9. doi: 10.1021/ol303306s. Epub 2012 Dec 20.
PMID:23256788
Abstract
Judicious design of BODIPY dyes carrying nitroethenyl substituents in conjugation with the BODIPY core yields dyes that respond to biological thiols by both absorbance and emission changes. Incorporation of solubilizing ethyleneglycol units ensures water solubility. The result is bright signaling of biologically relevant thiols in the longer wavelength region of the visible spectrum and in aqueous solutions.
摘要
明智地设计带有硝基亚乙烯取代基的 BODIPY 染料，使其与 BODIPY 核心共轭，可产生通过吸收和发射变化响应生物硫醇的染料。引入增溶的乙二醇单元可确保水溶性。结果是在可见光谱的较长波长区域和水溶液中生物相关硫醇的明亮信号。
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