血色素沉着症会引发乳糜泻吗？一项对29096名乳糜泻患者的研究。
Does hemochromatosis predispose to celiac disease? A study of 29,096 celiac disease patients.
作者信息
Ludvigsson Jonas F, Murray Joseph A, Adams Paul C, Elmberg Maria
机构信息
Department of Paediatrics, Örebro University Hospital, Sweden.
出版信息
Scand J Gastroenterol. 2013 Feb;48(2):176-82. doi: 10.3109/00365521.2012.749511. Epub 2012 Dec 20.
BACKGROUND AND AIM
Case reports suggest an association between hereditary hemochromatosis (HH) and celiac disease (CD), but estimates of association are lacking. We estimated the association between HH and CD in a population-based study.
MATERIAL AND METHODS
Case-control study. We identified 29,096 individuals with biopsy-verified CD (equal to villous atrophy, Marsh stage III) through biopsy reports from all 28 pathology departments in Sweden. We then investigated the risk of a clinical diagnosis of HH in CD and in 144,522 controls matched for age, sex, county and calendar year. Conditional logistic regression was used to calculate odds ratios (ORs) for CD in patients with HH.
RESULTS
HH was seen in 30 patients with CD and in 60 matched controls. HH was hence associated with an increased risk of CD (OR = 2.30; 95% CI = 1.53-3.45). Restricting HH to individuals with at least two records of HH, the OR for CD was 2.54 (95% CI = 1.57-4.11), with a similar risk estimate when we only looked at HH diagnosed before CD (and matched date in controls) (OR = 2.64; 95% CI = 1.24-5.60).
CONCLUSION
HH seems to be associated with an increased risk of CD.
背景与目的
病例报告提示遗传性血色素沉着症（HH）与乳糜泻（CD）之间存在关联，但缺乏关联度的评估。我们在一项基于人群的研究中评估了HH与CD之间的关联。
材料与方法
病例对照研究。我们通过瑞典所有28个病理科的活检报告，识别出29096例经活检证实为CD（等同于绒毛萎缩，马什III期）的个体。然后我们调查了CD患者以及144522名年龄、性别、县和日历年匹配的对照者临床诊断为HH的风险。采用条件逻辑回归计算HH患者患CD的比值比（OR）。
结果
在30例CD患者和60例匹配对照者中发现了HH。因此，HH与CD风险增加相关（OR = 2.30；95%CI = 1.53 - 3.45）。将HH限定为至少有两条HH记录的个体时，CD的OR为2.54（95%CI = 1.57 - 4.11），当我们仅观察在CD之前诊断的HH（以及对照者的匹配日期）时，风险估计相似（OR = 2.64；95%CI = 1.24 - 5.60）。
结论
HH似乎与CD风险增加相关。
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