Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.
J Invest Dermatol. 2011 Oct;131(10):2010-6. doi: 10.1038/jid.2011.162. Epub 2011 Jun 9.
Earlier studies on the association between celiac disease (CD) and psoriasis show contradictory results. The purpose of this study was to assess the risk of psoriasis in patients with biopsy-verified CD. Through 28 pathology departments in Sweden, we identified individuals with CD diagnosed between 1969 and 2008 (Marsh 3: villous atrophy; n = 28,958 unique individuals). We then used Cox regression to compare individuals with CD with 143,910 sex- and age-matched controls regarding their risk of psoriasis. CD was a risk factor for future psoriasis (hazard ratio (HR) = 1.72; 95% confidence interval (CI) = 1.54-1.92; during follow-up, 401 individuals with CD and 1,139 controls had a diagnosis of psoriasis). The absolute risk of future psoriasis in patients with CD was 135/100,000 person-years (excess risk = 57/100,000). In all, 42% of all psoriasis in patients with CD could be attributed to the underlying CD. Moreover, in children we saw a positive association between CD and psoriasis (HR = 2.05; 95% CI = 1.62-2.60). The association between CD and psoriasis seems to be independent of a temporal relationship, as we also found a positive association between CD and psoriasis before CD diagnosis (odds ratio = 1.91; 95% CI = 1.58-2.31). In conclusion, individuals with CD were at increased risk of psoriasis both before and after CD diagnosis.
先前关于乳糜泻（CD）和银屑病之间关联的研究结果相互矛盾。本研究旨在评估经活检证实的 CD 患者患银屑病的风险。我们通过瑞典 28 个病理部门，确定了 1969 年至 2008 年间诊断为 CD 的个体（独特个体 28958 人）。然后，我们使用 Cox 回归比较了 CD 患者和 143910 名性别和年龄匹配的对照者患银屑病的风险。CD 是未来患银屑病的一个危险因素（危险比（HR）=1.72；95%置信区间（CI）=1.54-1.92；在随访期间，401 名 CD 患者和 1139 名对照者被诊断为银屑病）。CD 患者未来患银屑病的绝对风险为 135/100000 人年（超额风险=57/100000）。总之，CD 患者中 42%的银屑病可归因于潜在的 CD。此外，我们还发现儿童 CD 与银屑病之间存在正相关（HR=2.05；95%CI=1.62-2.60）。CD 和银屑病之间的关联似乎与时间关系无关，因为我们还发现 CD 诊断前 CD 和银屑病之间也存在正相关（比值比=1.91；95%CI=1.58-2.31）。总之，CD 患者在 CD 诊断前后均患银屑病的风险增加。
