Flickinger John C, Kano Hideyuki, Niranjan Ajay, Kondziolka Douglas, Lunsford L Dade
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
Prog Neurol Surg. 2013;27:49-57. doi: 10.1159/000341623. Epub 2012 Dec 11.
Selection of the prescription dose for arteriovenous malformation (AVM) radiosurgery is the final step in treatment planning. Physicians need to choose a prescription dose that provides an optimal middle ground between optimizing AVM obliteration with high radiation doses and limiting complication risks with the lowest doses. Accurately predicting complication risks for individual patients is a complex process that is highly dependent on the radiosurgery treatment volume, the target location and the nature of the target tissue. This article reviews the principles and data guiding dose selection for AVM radiosurgery.
选择动静脉畸形（AVM）放射外科手术的处方剂量是治疗计划的最后一步。医生需要选择一个处方剂量，在以高辐射剂量优化AVM闭塞和以最低剂量限制并发症风险之间找到最佳平衡点。准确预测个体患者的并发症风险是一个复杂的过程，高度依赖于放射外科手术的治疗体积、靶区位置和靶组织的性质。本文综述了指导AVM放射外科手术剂量选择的原则和数据。
