Flickinger J C, Kondziolka D, Lunsford L D
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Neurosurg Clin N Am. 1999 Apr;10(2):271-80.
Selection of the prescription dose for radiosurgery is the final step in treatment planning. Dose selection should take into account the expectation of treatment success (i.e., tumor control, arteriovenous malformation [AVM] obliteration, and so forth) and complication risks at various doses. Accurately predicting complication risks for individual patients is a complex process that is highly dependent on the radiosurgery treatment volume, the target location, and the nature of the target tissue. Dose-response data for desired outcomes of radiosurgery are sparse and difficult to interpret for most indications, with perhaps the exception of AVM obliteration. This article reviews the principles governing dose-selection and the evolving body of data guiding dose selection in radiosurgery.
放射外科治疗中处方剂量的选择是治疗计划的最后一步。剂量选择应考虑治疗成功的预期（即肿瘤控制、动静脉畸形[AVM]闭塞等）以及不同剂量下的并发症风险。准确预测个体患者的并发症风险是一个复杂的过程，高度依赖于放射外科治疗体积、靶区位置和靶组织的性质。除了AVM闭塞可能是个例外，对于放射外科大多数适应证，关于期望治疗结果的剂量反应数据稀少且难以解读。本文回顾了放射外科剂量选择的指导原则以及指导剂量选择的不断发展的数据。
