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Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation.Akt2基因敲除通过挽救心脏自噬体成熟来维持高脂饮食诱导肥胖状态下的心脏功能。
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2
Deletion of protein kinase B2 preserves cardiac function by blocking interleukin-6-mediated injury and restores blood pressure during angiotensin II/high-salt-diet-induced hypertension.蛋白激酶 B2 的缺失通过阻断白细胞介素-6 介导致伤来保护心脏功能，并在血管紧张素 II/高盐饮食诱导的高血压期间恢复血压。
J Hypertens. 2018 Apr;36(4):834-846. doi: 10.1097/HJH.0000000000001613.
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Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent.锌对Akt2基因缺失相关的小鼠心脏功能障碍和病理变化的挽救作用是依赖金属硫蛋白的。
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Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart.成纤维细胞生长因子 21 通过 AMPK 介导的抗氧化和降脂作用预防糖尿病心肌病。
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Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice.肝 mTOR-AKT2-Insig2 信号通路有助于改善小鼠 Roux-en-Y 胃旁路术后的肝脂肪变性。
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Cell Physiol Biochem. 2018;48(4):1543-1555. doi: 10.1159/000492264. Epub 2018 Aug 2.
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Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction.AMP 激活的蛋白激酶缺乏会加剧高脂肪饮食诱导的心脏肥大和收缩功能障碍。
J Mol Cell Cardiol. 2011 Apr;50(4):712-22. doi: 10.1016/j.yjmcc.2010.12.007. Epub 2010 Dec 16.

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JACC Basic Transl Sci. 2025 Apr;10(4):475-497. doi: 10.1016/j.jacbts.2024.11.006. Epub 2025 Jan 22.
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Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition: Harnessing the power of nanotheranostics.自噬和线粒体自噬作为糖尿病心脏疾病的潜在治疗靶点：利用纳米诊疗技术的力量
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Nontargeted Metabolomic Profiling of Huo-Tan-Chu-Shi Decoction in the Treatment of Coronary Heart Disease with Phlegm-damp Syndrome.化痰祛湿方治疗冠心病痰浊证的非靶向代谢组学分析
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Advances in cGAS-STING Signaling Pathway and Diseases.cGAS-STING信号通路与疾病的研究进展
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9
Ablation of Akt2 and AMPK2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy.敲除Akt2和AMPK2可通过帕金蛋白介导的线粒体自噬挽救高脂饮食诱导的肥胖和肝脂肪变性。
Acta Pharm Sin B. 2021 Nov;11(11):3508-3526. doi: 10.1016/j.apsb.2021.07.006. Epub 2021 Jul 14.
10
Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology.心血管病理生物学中的自噬的表观遗传调控。
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本文引用的文献

1
Autophagy as a therapeutic target in cardiovascular disease.自噬作为心血管疾病的治疗靶点。
J Mol Cell Cardiol. 2011 Oct;51(4):584-93. doi: 10.1016/j.yjmcc.2011.06.010. Epub 2011 Jun 23.
2
Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy.组蛋白去乙酰化酶（HDAC）抑制剂通过抑制自噬来减轻心肌肥厚。
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8. doi: 10.1073/pnas.1015081108. Epub 2011 Feb 18.
3
High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.高脂肪饮食诱导的肥胖和心脏功能障碍受果蝇 TOR 通路的调节。
Cell Metab. 2010 Nov 3;12(5):533-44. doi: 10.1016/j.cmet.2010.09.014.
4
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.Sirt1 介导的 FoxO 去乙酰化在介导饥饿诱导的心肌细胞自噬中起关键作用。
Circ Res. 2010 Dec 10;107(12):1470-82. doi: 10.1161/CIRCRESAHA.110.227371. Epub 2010 Oct 14.
5
Methods in mammalian autophagy research.哺乳动物自噬研究方法。
Cell. 2010 Feb 5;140(3):313-26. doi: 10.1016/j.cell.2010.01.028.
6
Novel methods for measuring cardiac autophagy in vivo.体内测量心脏自噬的新方法。
Methods Enzymol. 2009;453:325-42. doi: 10.1016/S0076-6879(08)04016-0.
7
Cardiac autophagy is a maladaptive response to hemodynamic stress.心脏自噬是对血流动力学应激的一种适应性不良反应。
J Clin Invest. 2007 Jul;117(7):1782-93. doi: 10.1172/JCI27523.
8
Protein turnover via autophagy: implications for metabolism.通过自噬进行的蛋白质周转：对新陈代谢的影响。
Annu Rev Nutr. 2007;27:19-40. doi: 10.1146/annurev.nutr.27.061406.093749.
9
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.p62/SQSTM1形成通过自噬降解的蛋白质聚集体，并对亨廷顿蛋白诱导的细胞死亡具有保护作用。
J Cell Biol. 2005 Nov 21;171(4):603-14. doi: 10.1083/jcb.200507002. Epub 2005 Nov 14.
10
Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload.用雷帕霉素抑制mTOR信号通路可使由压力超负荷诱导的已形成的心脏肥大消退。
Circulation. 2004 Jun 22;109(24):3050-5. doi: 10.1161/01.CIR.0000130641.08705.45. Epub 2004 Jun 7.

Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation.

作者信息

Xu Xihui, Hua Yinan, Nair Sreejayan, Zhang Yingmei, Ren Jun

出版信息

J Mol Cell Biol. 2013 Feb;5(1):61-3. doi: 10.1093/jmcb/mjs055. Epub 2012 Dec 19.

DOI:10.1093/jmcb/mjs055
PMID:23258696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3695604/
Abstract
摘要