Medical Biology Unit, Medical University of Lublin, 20-059 Lublin, Poland.
Evid Based Complement Alternat Med. 2012;2012:606183. doi: 10.1155/2012/606183. Epub 2012 Nov 26.
The aim of the study was to evaluate the effect of resveratrol in doxorubicin-induced cardiac and hepatic toxicity. Doxorubicin was administered once a week throughout the period of 7 weeks with 1.0 or 2.0 mg/kg body weight or concomitantly with resveratrol (20 mg/kg of feed). Heart and liver toxicity was histologically and biochemically evaluated. Resveratrol protected from the heart lipid peroxidation caused by 1 mg doxorubicin and it sharply diminished superoxide dismutase activity. An insignificant effect of resveratrol on the lipid peroxidation level and the superoxide dismutase activity was observed in the hearts of rats administered a higher dose of doxorubicin. However, resveratrol attenuate necrosis and other cardiac histopathological changes were induced by a high dose of doxorubicin. Interestingly, it slightly intensified adverse cardiac histological changes in rats receiving a lower dose of doxorubicin. Resveratrol did not have any protective effect on the hepatic oxidative stress, while exerting a mild beneficial effect on the morphological changes caused by doxorubicin. All in all, this study has shown different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity. Resveratrol may modulate the hepatic and cardiac effect of doxorubicin, depending on the drug dose.
这项研究的目的是评估白藜芦醇对阿霉素诱导的心脏和肝脏毒性的影响。阿霉素每周给药一次，持续 7 周，剂量为 1.0 或 2.0mg/kg 体重，或同时给予白藜芦醇（饲料 20mg/kg）。通过组织学和生化方法评估心脏和肝脏毒性。白藜芦醇可防止 1mg 阿霉素引起的心脏脂质过氧化，同时明显降低超氧化物歧化酶活性。在给予高剂量阿霉素的大鼠心脏中，白藜芦醇对脂质过氧化水平和超氧化物歧化酶活性的影响不显著。然而，白藜芦醇可减轻高剂量阿霉素引起的坏死和其他心脏组织病理学变化。有趣的是，它略微加重了接受低剂量阿霉素的大鼠的不良心脏组织病理学变化。白藜芦醇对肝脏氧化应激没有任何保护作用，但对阿霉素引起的形态变化有轻微的有益作用。总的来说，这项研究表明，白藜芦醇对剂量相关的阿霉素诱导的心脏和肝脏毒性有不同的作用。白藜芦醇可能根据药物剂量调节阿霉素的肝和心脏作用。
