Hendriks R, Bornstein J C, Furness J B
Department of Physiology, Flinders University of South Australia, Bedford Park.
Neurosci Lett. 1990 Mar 14;110(3):286-90. doi: 10.1016/0304-3940(90)90861-3.
Conduction of action potentials in the processes of AH (afterhyperpolarizing) neurons has been examined in the myenteric plexus of the guinea-pig small intestine. AH neurons are a morphologically distinct class of myenteric neurons in which the action potentials are followed by long lasting afterhyperpolarizations and which usually lack fast synaptic inputs. These neurons have large smooth cell bodies and several long processes. We have used electrophysiological methods, combined with intracellular injection of the fluorescent dye 5(6)-carboxyfluorescein, to examine the directions of projection and lengths of axons of AH neurons. AH neurons of the myenteric plexus projected circumferentially in both directions from the cell soma for electrophysiologically determined average distances of 0.74 +/- 0.05 mm. Thus, the neurons span about 1.5 mm of the circumference of the intestine. About one quarter of the AH neurons had one, or rarely two, processes that ran anally after initially projecting circumferentially. All processes conducted action potentials, with average conduction velocities of 0.23 +/- 0.02 ms-1.
已在豚鼠小肠肌间神经丛中研究了AH（超极化后）神经元突起中动作电位的传导。AH神经元是肌间神经丛中一类形态上独特的神经元，其动作电位之后是持续时间较长的超极化后电位，并且通常缺乏快速突触输入。这些神经元具有大的光滑细胞体和几条长突起。我们使用电生理方法，并结合向细胞内注射荧光染料5(6)-羧基荧光素，来研究AH神经元的投射方向和轴突长度。肌间神经丛的AH神经元从细胞体沿圆周向两个方向投射，经电生理测定平均距离为0.74±0.05毫米。因此，这些神经元跨越约1.5毫米的肠周径。约四分之一的AH神经元有一个，或很少有两个，在最初沿圆周投射后向肛门方向延伸的突起。所有突起都能传导动作电位，平均传导速度为0.23±0.02米/秒。
