Check J H, Nowroozi K, Winkel C A, Johnson T, Seefried L
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden.
Obstet Gynecol. 1990 May;75(5):742-4.
CA 125 has been found in high concentrations in human amniotic fluid throughout gestation, with significant quantities seen in the decidua and chorion. Because disruption of the epithelial basement membrane of the fetal membrane or the decidua could theoretically lead to a rise in maternal CA 125 levels, this increase may be a predictor of subsequent spontaneous abortion of the fetus. A study was initiated to investigate whether a sudden rise in the serum CA 125 level might predict spontaneous first-trimester abortions. CA 125 levels of 101 pregnant women were evaluated 18-22 days from conception and 6 weeks from conception (a frequent time for spontaneous abortion) to determine whether there is a sudden increase (from baseline or early trimester levels) during the middle or late first trimester immediately before or at the time of abortion. The results indicated that although there was a definite correlation found between elevation of CA 125 and spontaneous abortion, the higher levels occurred early in the first trimester whereas the majority of abortions did not occur until much later, after fetal viability was established. Six of ten women with CA 125 levels of 150 U/mL or greater aborted, compared with four of 92 women with CA 125 levels less than 150 U/mL. One of 11 women pregnant after in vitro fertilization had a CA 125 level above 150 U/mL, and she aborted.
在整个孕期的人羊水中均发现CA 125浓度较高，在蜕膜和绒毛膜中也可见大量CA 125。由于胎膜或蜕膜的上皮基底膜破坏理论上可能导致母体CA 125水平升高，这种升高可能是胎儿随后自然流产的一个预测指标。开展了一项研究，以调查血清CA 125水平突然升高是否可能预测孕早期自然流产。对101名孕妇在受孕后18 - 22天以及受孕后6周（自然流产的常见时间）的CA 125水平进行评估，以确定在孕早期中期或晚期、流产前或流产时是否有突然升高（相对于基线水平或孕早期早期水平）。结果表明，虽然CA 125升高与自然流产之间存在明确关联，但较高水平出现在孕早期早期，而大多数流产直到胎儿存活确立后很久才发生。CA 125水平为150 U/mL或更高的10名女性中有6人流产，而CA 125水平低于150 U/mL的92名女性中有4人流产。11名体外受精后怀孕的女性中有1人CA 125水平高于150 U/mL，她流产了。
