UO Geriatria, Ospedale di Montefiascone, Montefiascone 01027, Italy
BMC Cardiovasc Disord. 2012 Dec 23;12:124. doi: 10.1186/1471-2261-12-124.
Aim of the study was to assess QTc interval by a 24-hour ECG recording in a group of HIV-infected individuals with a basal prolonged QTc. The risk factors associated with QTc prolongation and the indices of cardiovascular autonomic control were also evaluated.
A case-control study was performed using as cases 32 HIV-infected patients with prolonged (>440 msec) QTc interval as assessed by Holter ECG, and as controls 64 HIV-infected subjects with normal QTc interval. Autonomic function was evaluated by heart rate variability analysis during 24-hour recording.
Duration of HIV disease was significantly longer among cases than among controls (p=0.04). Waist/hip ratio was also higher among cases than among controls (p=0.05). Frequency domain analysis showed the absence of physiologic decrease of low frequency (LF) in the night period in both cases and controls. The LF night in cases showed a statistically significant reduction when compared with controls (p=0.007).
In our study group, QTc interval prolongation was associated with a longer duration of HIV infection and with a greater waist/hip ratio. HIV patients with QTc interval prolongation and with a longer duration of HIV infection were more likely to have an impairment of parasympathetic and sympathetic cardiac component.
本研究旨在通过对一组基础 QTc 延长的 HIV 感染者进行 24 小时心电图记录来评估 QTc 间期。还评估了与 QTc 延长相关的危险因素和心血管自主控制指数。
采用病例对照研究，将 32 例经动态心电图评估 QTc 延长（>440msec）的 HIV 感染者作为病例，64 例 QTc 正常的 HIV 感染者作为对照。通过 24 小时记录期间的心率变异性分析评估自主神经功能。
与对照组相比，病例组的 HIV 病期明显更长（p=0.04）。病例组的腰围/臀围比也高于对照组（p=0.05）。频域分析显示，病例组和对照组夜间低频（LF）的生理性降低均缺失。与对照组相比，病例组的 LF 夜间显著减少（p=0.007）。
在我们的研究组中，QTc 间期延长与 HIV 感染时间延长和腰围/臀围比增大有关。QTc 间期延长且 HIV 感染时间较长的 HIV 患者更可能存在副交感和交感心脏成分的损害。
