Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Org Lett. 2013 Jan 4;15(1):196-9. doi: 10.1021/ol303259m. Epub 2012 Dec 21.
A cobalt-triarylphosphine catalyst promotes an annulation reaction of an α,β-unsaturated imine and an internal alkyne to afford a polysubstituted dihydropyridine derivative in good yield under mild conditions. The reaction likely involves alkenylation of the olefinic C-H bond via cobalt-mediated nitrogen-assisted C-H activation followed by facile 6π electrocyclization of the resulting azatriene intermediate.
一种钴-三芳基膦催化剂促进了α,β-不饱和亚胺和内部炔烃的环化反应，在温和条件下以良好的收率得到多取代的二氢吡啶衍生物。该反应可能涉及通过钴介导的氮辅助 C-H 活化使烯烃 C-H 键烯丙化，然后通过生成的氮杂环丙烯中间体的易发生的 6π 电环化。
