Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, California, USA.
Diabetes Care. 2012 Mar;35(3):526-8. doi: 10.2337/dc11-1641.
To report frequencies of gestational diabetes mellitus (GDM) among the 15 centers that participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study using the new International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria.
All participants underwent a 75-g oral glucose tolerance test between 24 and 32 weeks' gestation. GDM was retrospectively classified using the IADPSG criteria (one or more fasting, 1-h, or 2-h plasma glucose concentrations equal to or greater than threshold values of 5.1, 10.0, or 8.5 mmol/L, respectively).
Overall frequency of GDM was 17.8% (range 9.3-25.5%). There was substantial center-to-center variation in which glucose measures met diagnostic thresholds.
Although the new diagnostic criteria for GDM apply globally, center-to-center differences occur in GDM frequency and relative diagnostic importance of fasting, 1-h, and 2-h glucose levels. This may impact strategies used for the diagnosis of GDM.
报告参加高血糖与不良妊娠结局（HAPO）研究的 15 个中心中，使用新的国际妊娠合并糖尿病研究组织（IADPSG）标准，妊娠期糖尿病（GDM）的发生频率。
所有参与者均在妊娠 24 至 32 周时进行 75g 口服葡萄糖耐量试验。采用 IADPSG 标准（1 项或多项空腹、1h 或 2h 血浆葡萄糖浓度等于或大于 5.1、10.0 或 8.5mmol/L 的阈值）对 GDM 进行回顾性分类。
GDM 的总发生率为 17.8%（范围为 9.3%-25.5%）。各中心间葡萄糖检测值符合诊断标准的情况存在显著差异。
尽管 GDM 的新诊断标准在全球范围内适用，但 GDM 的发生率以及空腹、1h 和 2h 血糖水平的相对诊断重要性存在中心间差异。这可能会影响 GDM 的诊断策略。
