表皮葡萄球菌血流分离株中的利奈唑胺依赖。
Linezolid dependence in Staphylococcus epidermidis bloodstream isolates.
机构信息
Department of Microbiology, University of Thessaly Medical School, Larissa, Greece.
出版信息
Emerg Infect Dis. 2013 Jan;19(1):129-32. doi: 10.3201/eid1901.111527.
Abstract
We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.
摘要
我们记录了 5 株高度耐(linezolid-resistant, LRSE) 表皮葡萄球菌血流分离株的利奈唑胺依赖性，这些分离株在 32 µg/mL 利奈唑胺存在下生长速度显著加快。这些分离株在多个 23S rRNA 拷贝中携带 T2504A 和 C2534T 突变，以及导致 L3 蛋白中相关氨基酸取代的 2 个突变。利奈唑胺依赖性可能导致 LRSE 的出现增加。
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