Laboratoire de Nanomédecine, Imagerie et Thérapeutiques, Université de Franche-Comté, Centre Hospitalier Universitaire de Besançon, 16, route de Gray, 25000 Besançon, France.
J Biotechnol. 2013 Mar 10;164(1):13-8. doi: 10.1016/j.jbiotec.2012.12.008. Epub 2012 Dec 20.
We report molecular dynamic simulations showing that a DNA molecule constituted by five unique bases can be spontaneously inserted into single walled carbon nanotube (SWCNT) in normal conditions (P, T and water environment) depending on the tube radius value. The van der Waals and electrostatic interactions play a central role for the rapid insertion process. Our study shows also that the Guanine molecule inserts the fastest compared to thymine, adenine and cytosine bases, respectively. The differences of insertion time could be exploited for applications concerning for example DNA sequencing.
我们报告了分子动力学模拟结果,表明在正常条件下(P、T 和水环境),取决于管半径值,由五个独特碱基组成的 DNA 分子可以自发地插入单壁碳纳米管(SWCNT)中。范德华力和静电力在快速插入过程中起着核心作用。我们的研究还表明,与胸腺嘧啶、腺嘌呤和胞嘧啶碱基相比,鸟嘌呤分子的插入速度最快。插入时间的差异可用于例如 DNA 测序等应用。