Boukari Khaoula, Caoduro Cécile, Kacem Raoudha, Skandrani Nadia, Borg Christophe, Boulahdour Hatem, Gharbi Tijani, Delage-Mourroux Régis, Hervouet Eric, Pudlo Marc, Picaud Fabien
Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.
Inserm 1098, EFS Bourgogne Franche Comté, University of Bourgogne Franche-Comté IFR133, Besancon, France.
J Membr Biol. 2016 Aug;249(4):493-501. doi: 10.1007/s00232-016-9890-5. Epub 2016 Mar 24.
Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.
碳纳米管（CNT）目前被用作一类有前景的纳米载体，能够递送不同类型的治疗分子。自从其穿透细胞的能力得到证实以来，已经开发了几种将CNT用作药物纳米载体的应用。因此，CNT可以将多种活性分子加载到各种细胞中。在本文中，我们将使用分子动力学模拟从理论上描述CNT通过形成鱼精蛋白-DNA-CNT复合物来转运和递送DNA的潜力。
