Snyder B W, Beecham G D, Winneker R C
Department of Pharmacology, Sterling Research Group, Rensselaer, New York 12144.
Proc Soc Exp Biol Med. 1990 May;194(1):54-7. doi: 10.3181/00379727-194-43054.
Previous studies had indicated that the effects of danazol on rat peripheral tissues were mediated through both androgen and estrogen receptors. The purpose of this study was to examine the role of androgen and estrogen receptors in danazol suppression of luteinizing hormone (LH) in the rat. The estrogen receptor antagonist, LY 156758, partially antagonized the suppressed levels of LH observed 3-5 hr after administration of danazol to ovariectomized rats. In contrast, the androgen receptor antagonist, flutamide, had no effect on suppressed LH levels 3-5 hr after danazol, but did partially reverse the inhibition of LH 24 hr after danazol administration to ovariectomized rats. Danazol also increased pituitary progesterone receptor levels, an estrogen-sensitive end point. These data indicate that the suppressed levels of LH following danazol treatment resulted from the functional activation of both androgen and estrogen receptors.
先前的研究表明，达那唑对大鼠外周组织的作用是通过雄激素和雌激素受体介导的。本研究的目的是研究雄激素和雌激素受体在达那唑抑制大鼠促黄体生成素（LH）中的作用。雌激素受体拮抗剂LY 156758部分拮抗了给去卵巢大鼠注射达那唑后3至5小时观察到的LH抑制水平。相比之下，雄激素受体拮抗剂氟他胺对注射达那唑后3至5小时的LH抑制水平没有影响，但在给去卵巢大鼠注射达那唑24小时后确实部分逆转了LH的抑制作用。达那唑还增加了垂体孕酮受体水平，这是一个雌激素敏感的终点。这些数据表明，达那唑治疗后LH水平的抑制是由雄激素和雌激素受体的功能激活导致的。
