School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Chem Soc Rev. 2013 Jun 7;42(11):4599-612. doi: 10.1039/c2cs35413f. Epub 2012 Dec 21.
Because of the importance of carbohydrate-protein interactions in biological processes, the development of glycoclusters and glycodendrimers capable of mimicking the multivalent display of carbohydrates at the cell surface has become a major field of research over the last decade. Among the large variety of scaffolds that are now available, peptides and cyclopeptides are widely used for the multivalent presentation of glycans. This review will provide an overview of the most recent advances in the preparation and utilization of linear glycopeptides and glycocyclopeptides in glycobiology.
由于碳水化合物-蛋白质相互作用在生物过程中的重要性，过去十年中，能够模拟碳水化合物在细胞表面的多价展示的糖缀合物和糖树状聚合物的开发已成为一个主要的研究领域。在现在可用的各种支架中，肽和环肽被广泛用于糖的多价展示。这篇综述将概述糖生物学中线性糖肽和糖环肽的制备和利用的最新进展。
