Daskhan Gour Chand, Berthet Nathalie, Thomas Baptiste, Fiore Michele, Renaudet Olivier
Univ. Grenoble Alpes, DCM, 38000 Grenoble, France; CNRS, DCM, 38000 Grenoble, France.
Univ. Grenoble Alpes, DCM, 38000 Grenoble, France; CNRS, DCM, 38000 Grenoble, France; Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005 Paris, France.
Carbohydr Res. 2015 Mar 20;405:13-22. doi: 10.1016/j.carres.2014.07.017. Epub 2014 Aug 1.
Cyclopeptides have recently emerged as attractive molecular scaffolds for the multivalent presentation of carbohydrates in a well-defined constrained spatial orientation. This mini-review describes the last advances on the synthesis and the biological applications of these particular structures, going from low molecular weight glycoclusters to fully synthetic nano-sized glycodendrimers.
环肽最近已成为一种有吸引力的分子支架,可用于以明确受限的空间取向多价呈现碳水化合物。这篇小型综述描述了这些特殊结构在合成和生物学应用方面的最新进展,从低分子量糖簇到全合成的纳米级糖树枝状大分子。