胆囊收缩素受体拮抗剂MK-329对猪采食量的影响。

Effects of the CCK receptor antagonist MK-329 on food intake in pigs.

作者信息

Ebenezer I S, de la Riva C, Baldwin B A

机构信息

AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.

出版信息

Physiol Behav. 1990 Jan;47(1):145-8. doi: 10.1016/0031-9384(90)90053-7.

DOI:10.1016/0031-9384(90)90053-7

PMID:2326329

Abstract

The cholecystokinin (CCK) receptor antagonist MK-329 (previously L364,718) was administered intravenously (IV) (17.5-140 micrograms/kg) to pigs trained to make operant responses for food reinforcements after 4 hr of food deprivation. MK-329 produced a dose-related increase in food intake during the 2-hr test period, with maximum increases occurring at a dose of 70 micrograms/kg. CCK (1 micrograms/kg IV) produced a short-term reduction in feeding and this effect was completely abolished by pretreating the animals with MK-329 (70 micrograms/kg). The present results lend support to the hypothesis that endogenous CCK is involved in satiety.

摘要

给经过训练在禁食4小时后通过操作性反应获取食物强化物的猪静脉注射（IV）胆囊收缩素（CCK）受体拮抗剂MK - 329（先前为L364,718）（17.5 - 140微克/千克）。在2小时的测试期内，MK - 329使食物摄入量呈剂量相关增加，在剂量为70微克/千克时增加量最大。CCK（1微克/千克静脉注射）使进食量短期减少，而用MK - 329（70微克/千克）预处理动物可完全消除这种作用。目前的结果支持内源性CCK参与饱腹感调节这一假说。