Wohlschläger J, Welter S, Stamatis G, Theegarten D, Hager T, Mairinger F, Worm K, Schmid K W, Müller K M
Institut für Pathologie und Neuropathologie, Universitätsklinik Essen, Universität Duisburg-Essen, Hufelandstrasse 55, Essen, Germany.
Pathologe. 2013 Jul;34(4):338-42. doi: 10.1007/s00292-012-1725-2.
Benign epithelial tumors of the tracheobronchial system and the lungs are exceedingly rare. These entities encompass squamous and glandular papillomas (as well as their mixed forms) and adenomas (alveolar adenoma, papillary adenoma, salivary gland-like pleomorphic and mucinous adenomas and mucinous cystadenomas). These tumors are considered to be biologically benign neoplasms; however, they can pose considerable diagnostic difficulties, especially during frozen section evaluation, as they can mimic malignant tumors and in particular they can resemble well differentiated papillary adenocarcinomas. As a result of the extreme rarity of these tumors only a few descriptive diagnostic series exist and a systematic investigation including molecular data does not exist. This article presents the case of a 64-year-old patient with a glandular papilloma of the right main bronchus including the immunohistochemical and molecular work-up as well as a review of the current literature.
气管支气管系统和肺部的良性上皮性肿瘤极为罕见。这些肿瘤包括鳞状和腺性乳头状瘤（以及它们的混合形式）和腺瘤（肺泡腺瘤、乳头状腺瘤、涎腺样多形性和黏液性腺瘤以及黏液性囊腺瘤）。这些肿瘤被认为是生物学上的良性肿瘤；然而，它们可能会带来相当大的诊断困难，尤其是在冰冻切片评估期间，因为它们可能会模仿恶性肿瘤，特别是可能类似于高分化乳头状腺癌。由于这些肿瘤极其罕见，仅有少数描述性诊断系列报道，且不存在包括分子数据在内的系统性研究。本文介绍了一名64岁患有右主支气管腺性乳头状瘤患者的病例，包括免疫组化和分子检查结果，以及对当前文献的综述。
