兴奋剂能否降低患有注意力缺陷多动障碍（ADHD）的青少年饮酒和使用药物的风险？一项关于渗透型缓释哌甲酯的前瞻性、为期24个月的开放标签研究的二次分析。
Do Stimulants Reduce the Risk for Alcohol and Substance Use in Youth With ADHD? A Secondary Analysis of a Prospective, 24-Month Open-Label Study of Osmotic-Release Methylphenidate.
作者信息
Hammerness Paul, Petty Carter, Faraone Stephen V, Biederman Joseph
机构信息
1 Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
2 State University of New York Upstate Medical University, Syracuse, NY, USA.
出版信息
J Atten Disord. 2017 Jan;21(1):71-77. doi: 10.1177/1087054712468051. Epub 2016 Jul 28.
OBJECTIVE
The purpose of this study was to examine the impact of stimulant treatment on risk for alcohol and illicit drug use in adolescents with ADHD.
METHOD
Analysis of data derived from a prospective open-label treatment study of adolescent ADHD ( n = 115, 76% male), and a historical, naturalistic sample of ADHD ( n = 44, 68% male) and non-ADHD youth ( n = 52, 73% male) of similar age and sex. Treatment consisted of extended-release methylphenidate in the clinical trial or naturalistic stimulant treatment. Self-report of alcohol and drug use was derived from a modified version of the Drug Use Screening Inventory.
RESULTS
Rates of alcohol and drug use in the past year were significantly lower in the clinical trial compared with untreated and treated naturalistic ADHD comparators, and similar to rates in non-ADHD comparators.
CONCLUSION
Well-monitored stimulant treatment may reduce the risk for alcohol and substance use in adolescent ADHD.
目的
本研究旨在探讨兴奋剂治疗对患有注意力缺陷多动障碍（ADHD）的青少年使用酒精和非法药物风险的影响。
方法
对来自一项青少年ADHD前瞻性开放标签治疗研究（n = 115，76%为男性）以及一个历史自然主义样本（ADHD患者n = 44，68%为男性，非ADHD青少年n = 52，73%为男性）的数据进行分析，这些样本年龄和性别相似。在临床试验中治疗采用缓释哌甲酯，在自然主义样本中采用自然兴奋剂治疗。酒精和药物使用情况通过对药物使用筛查量表的修改版进行自我报告获得。
结果
与未治疗和接受自然主义治疗的ADHD对照者相比，临床试验中过去一年的酒精和药物使用率显著更低，且与非ADHD对照者的使用率相似。
结论
经过良好监测的兴奋剂治疗可能会降低青少年ADHD患者使用酒精和药物的风险。
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