Weissleder R, Elizondo G, Wittenberg J, Lee A S, Josephson L, Brady T J
Department of Radiology, Massachusetts General Hospital, Boston.
Radiology. 1990 May;175(2):494-8. doi: 10.1148/radiology.175.2.2326475.
An ultrasmall superparamagnetic iron oxide (USPIO) preparation was evaluated as a potential intravenous contrast agent for lymph nodes. Relaxation time measurements and magnetic resonance (MR) imaging were performed in rats with normal lymph nodes and in rats with lymph node metastases. In normal animals, lymph node relaxation times decreased maximally within 24-48 hours after intravenous administration of USPIO. Twenty-four hours after administration, the T2 of normal lymph nodes had decreased from 74 msec +/- 2.2 to 30 msec +/- 0.7 (USPIO, 40 mumol of iron per kilogram) or 15 msec +/- 0.0 (200 mumol Fe/kg), whereas the T2 of metastatic nodes did not change. MR imaging of the animal model of nodal metastases confirmed the hypothesis that intravenously administered USPIO decreases signal intensity of normal but not metastatic nodes. A single intravenous administration of USPIO may allow detection of nodal metastases on the basis of signal intensity characteristics rather than the currently used, insensitive size characteristics.
一种超小型超顺磁性氧化铁（USPIO）制剂被评估为一种潜在的用于淋巴结的静脉内造影剂。在具有正常淋巴结的大鼠和具有淋巴结转移的大鼠中进行了弛豫时间测量和磁共振（MR）成像。在正常动物中，静脉注射USPIO后24 - 48小时内淋巴结弛豫时间最大程度降低。给药后24小时，正常淋巴结的T2从74毫秒±2.2降至30毫秒±0.7（USPIO，每千克铁40微摩尔）或15毫秒±0.0（200微摩尔铁/千克），而转移淋巴结的T2没有变化。淋巴结转移动物模型的MR成像证实了以下假设：静脉注射USPIO会降低正常淋巴结而非转移淋巴结的信号强度。单次静脉注射USPIO可能基于信号强度特征而非目前使用的不敏感的大小特征来检测淋巴结转移。
