Meidani Mohsen, Rezaei Farshid, Maracy Mohammad Reza, Avijgan Majid, Tayeri Katayoun
Assistant Profeessor, Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2012 Feb;17(2):138-42.
The prevalence of anemia in HIV infected patients has not been well characterized in Iran. This study aimed to describe the prevalence of anemia and related factors in HIV positive patients.
In a cross-sectional study, anemia prevalence and risk factors of 212 HIV positive patients were assessed, at the behavioral disease consulting center in Isfahan. The relationship between anemia, demographic variables, and clinical histories were analyzed. Mild to moderate anemia was defined as hemoglobin 8-13 g/dL for men and 8-12 g/dL for women. Severe anemia was defined as hemoglobin, 8 g/dL.
A total of 212 HIV positive patients with a mean±SD age of 36.1 ± 9.1 years were assessed. We found that hemoglobin levels were between 4.7 and 16.5 gr/dL. In this study, the overall prevalence of anemia was 71%, with the majority of patients having mild to moderate anemia. Mild to moderate anemia and severe anemia occurred in 67% and 4% of patients, respectively. The mean absolute CD4 count was 348 ± 267.8 cells/cubic mm. Sixty one of 212 patients were at late stage of HIV infection (males=51 and female=10). Of the 212 HIV positive patients enrolled, 17 (8%) had a positive history of tuberculosis. We found a strong association between anemia and death.
Normocytic anemia with decreased reticulocyte count was the most common type of anemia in overall. Prevalence of anemia in this study is relatively higher than other similar studies. Such a high prevalence of anemia needs close monitoring of patients on a zidovudine-based regimen. Better screening for anemia and infectious diseases, and modified harm reduction strategy (HRS) for injection drug users are primary needs in HIV seropositive patients.
伊朗尚未很好地描述艾滋病毒感染患者贫血的患病率。本研究旨在描述艾滋病毒阳性患者贫血的患病率及相关因素。
在一项横断面研究中，对伊斯法罕行为疾病咨询中心的212例艾滋病毒阳性患者的贫血患病率和危险因素进行了评估。分析了贫血与人口统计学变量及临床病史之间的关系。轻度至中度贫血定义为男性血红蛋白8 - 13 g/dL，女性血红蛋白8 - 12 g/dL。重度贫血定义为血红蛋白低于8 g/dL。
共评估了212例艾滋病毒阳性患者，平均年龄±标准差为36.1±9.1岁。我们发现血红蛋白水平在4.7至16.5 gr/dL之间。在本研究中，贫血的总体患病率为71%，大多数患者为轻度至中度贫血。轻度至中度贫血和重度贫血分别发生在67%和4%的患者中。平均绝对CD4细胞计数为348±267.8个/立方毫米。212例患者中有61例处于艾滋病毒感染晚期（男性51例，女性10例）。在纳入的212例艾滋病毒阳性患者中，17例（8%）有结核病史。我们发现贫血与死亡之间存在密切关联。
总体上，正细胞性贫血伴网织红细胞计数降低是最常见的贫血类型。本研究中贫血的患病率相对高于其他类似研究。如此高的贫血患病率需要对接受齐多夫定治疗方案的患者进行密切监测。对艾滋病毒血清阳性患者来说，更好地筛查贫血和传染病以及改进针对注射吸毒者的减少伤害策略是首要需求。
