Movahedi Mino, Saiedi Mahmoud, Gharipour Mojgan, Aghadavoudi Omid
Assistant Professor, Department of Gynecology and Obstetrician, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2012 Feb;17(2):164-6.
The measuring serum ferritin level as a sensitive inflammatory biomarker might effectively predict preterm delivery, but the power and the best cut-off point of this biomarker for predicting preterm labor in Iranian population has not been substantially identified. Our purpose was to determine what concentrations of serum ferritin could identify patients at risk for preterm delivery in Iranian population for the first time.
This case control study involved 222 singleton pregnancies that were referred to referral university hospitals clinics in Isfahan. Women with spontaneous preterm delivery before 24-26 weeks (preterm delivery group, n = 69) and those who delivered at term (term delivery group, n = 153) were compared with respect to serum ferritin concentration. Venous blood samples were analyzed for the serum ferritin level using the ferritin quantitative test system-sensitive for the normal ferritin range.
Women who delivered before 37 weeks had a higher mean serum ferritin concentration than those who delivered after 37 weeks of gestation (26.7 ± 5.5 ng/mL versus 19.8 ± 3.6 ng/mL, P<0.001). A serum ferritin level of 22.5 ng/mL yielded the best combination with sensitivity of 78.3%, specificity of 83.0%, positive predictive value of 67.5%, and negative predictive value of 89.4% for prediction of preterm delivery.
The serum ferritin level provides an appropriate discrimination in predicting preterm delivery with an optimal cut-off value of 22.5 ng/mL in Iranian population.
测量血清铁蛋白水平作为一种敏感的炎症生物标志物可能有效预测早产，但该生物标志物在伊朗人群中预测早产的效能及最佳临界值尚未得到充分确定。我们的目的是首次确定何种血清铁蛋白浓度可识别伊朗人群中早产风险患者。
本病例对照研究纳入了222例单胎妊娠，这些孕妇均转诊至伊斯法罕的大学附属医院诊所。比较了24 - 26周前自然早产的妇女（早产组，n = 69）和足月分娩的妇女（足月分娩组，n = 153）的血清铁蛋白浓度。使用对正常铁蛋白范围敏感的铁蛋白定量检测系统分析静脉血样本中的血清铁蛋白水平。
妊娠37周前分娩的妇女血清铁蛋白平均浓度高于妊娠37周后分娩的妇女（26.7±5.5 ng/mL对19.8±3.6 ng/mL，P<0.001）。血清铁蛋白水平为22.5 ng/mL时，预测早产的敏感性为78.3%，特异性为83.0%，阳性预测值为67.5%，阴性预测值为89.4%，是最佳组合。
在伊朗人群中，血清铁蛋白水平在预测早产方面具有良好的鉴别能力，最佳临界值为22.5 ng/mL。
