Kashanian Maryam, Bahasadri Shohreh, Ghasemi Afsaneh, Bathaee Saeedesadat
Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran.
J Obstet Gynaecol Res. 2013 Jan;39(1):26-30. doi: 10.1111/j.1447-0756.2012.01887.x. Epub 2012 May 28.
Preterm delivery is a serious problem during pregnancy with remarkable neonatal adverse effects. Prediction of preterm delivery in women with preterm uterine contractions or signs of preterm labor is critical because if these women are identified they can be referred to tertiary centers. The present study aimed to evaluate the value of maternal serum urocortin concentration for predicting preterm delivery in women with signs of spontaneous preterm labor.
A cohort study was conducted on pregnant women at a gestational age of 28-36 weeks who were admitted to the labor ward with spontaneous preterm labor. A blood sample was obtained from all participants to measure serum urocortin. The women were monitored up to delivery and serum urocortin was compared between women with preterm delivery and those who delivered at term (37 weeks of gestation). Receiver Operating Characteristic (ROC) curve analysis was used to determine sensitivity and specificity if applicable.
One hundred and sixty pregnant women finished the study. One hundred and forty-eight (92.5%) of the women delivered preterm. Mean serum urocortin in the preterm delivery group was higher than in the term group, but without statistical significant difference (392.6 ± 29.23 vs 113.2 ± 11.0. pg/mL, respectively, P = 0.252). Area under the ROC curve was 0.6, which shows that this test is not appropriate for predicting preterm delivery in women with preterm labor.
Serum urocortin could not predict women who delivered preterm among women with signs of preterm labor.
早产是孕期的一个严重问题，会对新生儿产生显著的不良影响。预测有子宫收缩早产迹象或早产征兆的女性发生早产至关重要，因为如果识别出这些女性，就可以将她们转诊至三级医疗中心。本研究旨在评估母体血清尿皮质素浓度对预测有自然早产迹象的女性发生早产的价值。
对孕周为28 - 36周、因自然早产入住产房的孕妇进行队列研究。采集所有参与者的血样以检测血清尿皮质素。对这些女性进行直至分娩的监测，并比较早产女性和足月分娩（妊娠37周）女性的血清尿皮质素水平。如果适用，采用受试者工作特征（ROC）曲线分析来确定敏感性和特异性。
160名孕妇完成了研究。其中148名（92.5%）女性早产。早产组的平均血清尿皮质素高于足月组，但差异无统计学意义（分别为392.6±29.23与113.2±11.0 pg/mL，P = 0.252）。ROC曲线下面积为0.6，这表明该检测方法不适用于预测有早产迹象的女性发生早产。
血清尿皮质素无法预测有早产迹象的女性中哪些会早产。
