The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames 11835, Cairo, Egypt.
Expert Rev Gastroenterol Hepatol. 2013 Jan;7(1):69-75. doi: 10.1586/egh.12.69.
The biological differences between males and females advocate the ultimate need for gender-specific medicine. The variation in response to viral infection as well as therapy among different genders makes it very intriguing to reveal the responsible factors for causing this discrepancy. HCV is one of the most noxious infectious diseases, however the impact of gender on the response to HCV has received negligible attention in the literature. The controversial studies concerning the effect of gender on the outcome of interferon-based therapy urge a need to judge the gender discrepancy in host factors responsible for both interferon release and action. The main aim of this review is to disentangle the interplay between sex hormones and several viral and host factors responsible for viral clearance in an attempt to clarify the role of gender in modulating the response to HCV as well as interferon-based therapy.
男女之间的生物学差异主张最终需要性别特异性药物。不同性别对病毒感染以及治疗的反应差异使得揭示导致这种差异的责任因素变得非常有趣。HCV 是最具危害性的传染病之一，然而，性别对 HCV 反应的影响在文献中几乎没有受到关注。关于性别对基于干扰素治疗结果的影响的有争议的研究促使人们需要判断宿主因素中与干扰素释放和作用有关的性别差异。本综述的主要目的是阐明性激素与几种病毒和宿主因素之间的相互作用，这些因素负责病毒清除，试图阐明性别在调节对 HCV 以及基于干扰素的治疗的反应中的作用。
