Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II , Via Montesano 49, 80131 Napoli, Italy.
J Nat Prod. 2013 Mar 22;76(3):346-53. doi: 10.1021/np3007149. Epub 2012 Dec 24.
During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.
在对 Helichrysum italicum subsp. microphyllum 中的倍半萜类 phloroglucinyl pyrone arzanol（1a）进行大规模分离活动期间，我们鉴定了几种新的酚类化合物和一类名为 santinols（5a-c、6-8）的不寻常类脂。santinols 是具有支链酰基或酮酰基链的 angeloylated 甘油酯，代表了迄今尚未报道的一类植物脂质。我们评估了 arzanol 和包括香豆酸酯、苯并呋喃、吡喃酮和倍半萜类 phloroglucinol 的一系列 Helichrysum 酚类化合物的抗菌活性，结果表明只有倍半二聚体对耐多药金黄色葡萄球菌具有很强的抗菌作用。这些观察结果证实了将 Helichrysum 提取物用于预防伤口感染的局部应用，这是地中海地区传统医学中确立的做法。
