Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA.
Org Lett. 2013 Jan 18;15(2):235-7. doi: 10.1021/ol303025m. Epub 2012 Dec 24.
Kynurenine, a metabolite of tryptophan, is known to contribute to cancer progression when overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been developed. When bound at low pH, sensor 1 undergoes a very large bathochromic shift because kynurenine extends the conjugation of the fluorophore. This unusual mechanism of activation provides a 390-fold fluorescence enhancement that is very specific to kynurenine and a wavelength of fluorescence that extends into the red.
犬尿氨酸是色氨酸的一种代谢物，当过量产生时，已知会促进癌症的发展。已经开发出一种使用传感器 1 轻松荧光检测犬尿氨酸的方法。当在低 pH 值下结合时，传感器 1 会发生非常大的红移，因为犬尿氨酸延长了荧光团的共轭。这种不寻常的激活机制提供了 390 倍的荧光增强，这对犬尿氨酸非常特异，并且荧光波长延伸到红色。
