Metabolic Diseases and Cell Signaling Research Group (MEDICS), Department of Biochemistry, University of Szeged Albert Szent-Györgyi Medical School, Szeged, Hungary.
Interdisciplinary Centre of Excellence, University of Szeged, Szeged, Hungary.
Front Immunol. 2022 Feb 8;12:768560. doi: 10.3389/fimmu.2021.768560. eCollection 2021.
Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc. contribute to the development of coronary atherosclerosis and subsequent coronary artery disease. Inflammation plays an important role in coronary artery disease development and progression. Pro-inflammatory signals promote the degradation of tryptophan the kynurenine pathway resulting in the formation of several immunomodulatory metabolites. An unbalanced kynurenic pathway has been implicated in the pathomechanisms of various diseases including CAD. Significant improvements in detection methods in the last decades may allow simultaneous measurement of multiple metabolites of the kynurenine pathway and such a thorough analysis of the kynurenine pathway may be a valuable tool for risk stratification and determination of CAD prognosis. Nevertheless, imbalance in the activities of different branches of the kynurenine pathway may require careful interpretation. In this review, we aim to summarize clinical evidence supporting a possible use of kynurenine pathway metabolites as clinical biomarkers in various manifestations of CAD.
冠状动脉疾病 (CAD) 是全球范围内导致死亡的主要原因之一。多种危险因素，包括不健康的生活方式、遗传背景、肥胖、糖尿病、高胆固醇血症、高血压、吸烟、年龄等，导致冠状动脉粥样硬化的发展和随后的 CAD。炎症在 CAD 的发展和进展中起着重要作用。促炎信号促进色氨酸的降解，导致几种免疫调节代谢物的形成。不平衡的犬尿氨酸途径与包括 CAD 在内的各种疾病的发病机制有关。在过去几十年中，检测方法的显著改进可能允许同时测量犬尿氨酸途径的多种代谢物，这种对犬尿氨酸途径的全面分析可能是进行风险分层和确定 CAD 预后的有价值的工具。然而，犬尿氨酸途径的不同分支的活性失衡可能需要仔细解释。在这篇综述中，我们旨在总结支持将犬尿氨酸途径代谢物作为 CAD 各种表现的临床生物标志物的临床证据。
