Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Pathog Glob Health. 2012 Aug;106(4):249-51. doi: 10.1179/2047773212Y.0000000030.
A 50-year-old villager with chronic inflammatory demyelinating polyradiculoneuropathy developed pain abdomen, diarrhea, and vomiting after 8 weeks of prednisolone (40 mg/day) therapy. After 10 weeks, he developed abdominal distension, leucocytosis, thrombocytopenia, liver dysfunction, coagulopathy, and respiratory failure. Stool examination showed larvae of Strongyloides stercoralis. He died in spite of antibiotics, metronidazole, ivermectin, vasopressor, and artificial ventilation. The patients on corticosteroid therapy are at risk of fatal septicemia due to Strongyloides stercoralis hyperinfection.
一位 50 岁的村民患有慢性炎症性脱髓鞘性多发性神经病,在接受泼尼松龙(40mg/天)治疗 8 周后出现腹痛、腹泻和呕吐。治疗 10 周后,他出现腹胀、白细胞增多、血小板减少、肝功能障碍、凝血功能障碍和呼吸衰竭。粪便检查显示有旋毛虫幼虫。尽管使用了抗生素、甲硝唑、伊维菌素、血管升压药和人工通气,他还是死亡了。接受皮质类固醇治疗的患者由于旋毛虫过度感染,有发生致命败血症的风险。