Lorcerie B, Grobost O, Lalu-Fraisse A, Piard F, Camus P, Portier H, Martin F
Service de Médecine I, Médecine Interne, C.H.U., Dijon.
Rev Med Interne. 1990 Jan-Feb;11(1):25-8. doi: 10.1016/s0248-8663(05)80604-6.
We report a case of peliosis hepatis in a 47-year old male patient with dermatomyositis treated with azathioprine and corticosteroids. Three months after the combined treatment was initiated, the patient developed right thoracic herpes zoster, agranulocytosis and liver enlargement with signs of portal hypertension. Needle biopsy of the liver revealed peliosis. Azathioprine was withdrawn. The clinical and laboratory abnormalities disappeared progressively. The main causes of peliosis hepatis are considered. Up to now, azathioprine had been held responsible for peliosis hepatis only in renal transplant recipients.
我们报告一例47岁男性皮肌炎患者，接受硫唑嘌呤和皮质类固醇治疗后发生肝紫癜。联合治疗开始三个月后，患者出现右胸带状疱疹、粒细胞缺乏症和肝脏肿大伴门静脉高压体征。肝脏穿刺活检显示为肝紫癜。停用硫唑嘌呤后，临床和实验室异常逐渐消失。文中考虑了肝紫癜的主要病因。迄今为止，硫唑嘌呤仅被认为是肾移植受者发生肝紫癜的原因。
