Knudsen Anette Hygum
Medicinsk gastroenterologisk afdeling S, Odense Universitetshospital, DK-5000 Odense.
Ugeskr Laeger. 2002 Jun 10;164(24):3215-6.
A case of peliosis hepatis in a 64-year-old woman treated with azathioprine because of a lung transplantation is described. The patient was admitted owing to epigastric pain and jaundice. Sixteen months before admission the patient had had a lung transplantation because of pulmonary emphysema. A liver biopsy showed multiple, dilated, blood-filled liver sinusoids consistent with peliosis hepatis. Besides azathioprine, the patient was treated with cyclosporine and prednisolone, but none of these drugs are known to be responsible for the development of peliosis hepatis. This rare condition, which causes liver affection in patients treated with azathioprine, should be kept in mind.
本文描述了一名64岁女性因肺移植接受硫唑嘌呤治疗后发生肝紫癜病的病例。该患者因上腹部疼痛和黄疸入院。入院前16个月，患者因肺气肿接受了肺移植。肝脏活检显示多个扩张的、充满血液的肝血窦，符合肝紫癜病表现。除硫唑嘌呤外，该患者还接受了环孢素和泼尼松龙治疗，但尚无已知这些药物会导致肝紫癜病的发生。在使用硫唑嘌呤治疗的患者中，应牢记这种可引起肝脏病变的罕见疾病。
