Szablewski Leszek
Centre of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
Biochim Biophys Acta. 2013 Apr;1835(2):164-9. doi: 10.1016/j.bbcan.2012.12.004. Epub 2012 Dec 21.
It has been known for 80 years that cancer cell growth in an energy-related process supported by an increased glucose metabolism. This phenomenon suggests a need for a corresponding increased uptake of glucose across the plasma membrane through an enhancement in the glucose transporter proteins, SGLT proteins as well as GLUT proteins. The results of many studies have demonstrated that the expression of glucose transporters, especially GLUT1, is increased in a variety of malignancies. GLUT1 overexpression has been found to be associated with tumor progression. It was found that GLUT1 overexpression is associated with poor overall survival in various malignant tumors.
80年来，人们已经知道癌细胞的生长是一个由葡萄糖代谢增加所支持的能量相关过程。这一现象表明，需要通过增强葡萄糖转运蛋白、钠-葡萄糖协同转运蛋白（SGLT蛋白）以及葡萄糖转运蛋白（GLUT蛋白）来相应增加葡萄糖跨质膜的摄取。许多研究结果表明，葡萄糖转运蛋白，尤其是GLUT1的表达在多种恶性肿瘤中增加。已发现GLUT1过表达与肿瘤进展相关。研究发现，GLUT1过表达与各种恶性肿瘤的总体生存率低相关。
