Saburi Ehsan, Moghbeli Meysam
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Clin Exp Med. 2025 Jun 15;25(1):206. doi: 10.1007/s10238-025-01757-1.
Chemotherapy is one of the most frequent therapeutic options in cancer patients. Cisplatin (CDDP) is widely used as one of the first-line platinum-based drugs in metastatic tumors. However, CDDP resistance is always one of the main therapeutic challenges in cancer patients. Considering the side effects of CDDP in cancer patients, the prediction of CDDP response can improve the management of tumor therapy. Therefore, it is necessary to investigate the molecular mechanisms involved in CDDP resistance in order to predict CDDP response in cancer patients. CDDP resistance is contributed with different cellular processes such as DNA repair, drug efflux, and signaling pathways. WNT/β-catenin pathway has a key role in tumor growth and drug resistance. β-catenin is considered as a key component of the WNT pathway, which can regulate the CDDP response in tumor cells by regulation of WNT target genes. In addition to the WNT pathway, β-catenin can also be regulated by the other signaling pathways. Deregulation of β-catenin is associated with CDDP resistance. Therefore, in the present review, we discussed the role of β-catenin in regulation CDDP response in tumor cells. It has been reported that β-catenin mainly promotes CDDP resistance in various cancers, whose function can be affected by other signaling pathways and transcription factors. This review can be an effective step toward introducing β-catenin as a prognostic marker as well as a therapeutic target in CDDP-resistant cancer patients.
化疗是癌症患者最常用的治疗选择之一。顺铂（CDDP）作为转移性肿瘤的一线铂类药物之一被广泛使用。然而，顺铂耐药一直是癌症患者主要的治疗挑战之一。考虑到顺铂对癌症患者的副作用，预测顺铂反应可以改善肿瘤治疗的管理。因此，有必要研究顺铂耐药涉及的分子机制，以便预测癌症患者的顺铂反应。顺铂耐药与DNA修复、药物外排和信号通路等不同的细胞过程有关。WNT/β-连环蛋白通路在肿瘤生长和耐药中起关键作用。β-连环蛋白被认为是WNT通路的关键组成部分，它可以通过调节WNT靶基因来调节肿瘤细胞中的顺铂反应。除了WNT通路，β-连环蛋白还可以被其他信号通路调节。β-连环蛋白的失调与顺铂耐药有关。因此，在本综述中，我们讨论了β-连环蛋白在调节肿瘤细胞顺铂反应中的作用。据报道，β-连环蛋白主要促进各种癌症中的顺铂耐药，其功能可受其他信号通路和转录因子的影响。本综述可能是朝着将β-连环蛋白作为顺铂耐药癌症患者的预后标志物和治疗靶点引入的有效一步。
