Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Cancer Lett. 2013 May 10;332(1):19-29. doi: 10.1016/j.canlet.2012.12.012. Epub 2012 Dec 22.
Metastasis is the primary mediator of prostate cancer (PCA) lethality and poses a significant clinical obstacle. The identification of factors involved in the metastasis of PCA is imperative. We demonstrate herein that trefoil factor 1 (TFF1) promotes PCA cell migration and invasion in vitro and metastasis in vivo. The capacity of TFF1 to enhance cell migration/invasion is mediated by transcriptional repression of E-CADHERIN. Consideration of targeted inhibition of TFF1 to prevent metastasis of prostate carcinoma is warranted.
转移是前列腺癌 (PCA) 致死的主要介导因素，也是一个重大的临床障碍。确定与 PCA 转移相关的因素至关重要。本文研究表明三叶因子 1（TFF1）可促进 PCA 细胞的体外迁移和侵袭以及体内转移。TFF1 增强细胞迁移/侵袭的能力是通过转录抑制 E-钙黏蛋白来介导的。考虑针对 TFF1 进行靶向抑制以防止前列腺癌转移是合理的。
