Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
Clin Chim Acta. 2013 Feb 18;417:39-44. doi: 10.1016/j.cca.2012.12.012. Epub 2012 Dec 22.
Beta-actin (ACTB) has traditionally been regarded as an endogenous housekeeping gene and has been widely used as a reference gene/protein in quantifying expression levels in tumors. However, ACTB is closely associated with a variety of cancers and accumulating evidence indicates that ACTB is de-regulated in liver, melanoma, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, ovarian cancers, leukemia and lymphoma. ACTB is generally found to be up-regulated in the majority of tumor cells and tissues. The abnormal expression and polymerization of ACTB and the resulting changes to the cytoskeleton are revealed to be associated with the invasiveness and metastasis of cancers. The current review explores relevant mechanisms, integrates current understandings, and provides suggestions for future studies of the roles of ACTB in tumors.
β-肌动蛋白（ACTB）传统上被视为内参看家基因，并且在肿瘤中作为定量表达水平的参考基因/蛋白被广泛应用。然而，ACTB 与多种癌症密切相关，并且越来越多的证据表明 ACTB 在肝、黑素瘤、肾、结直肠、胃、胰腺、食管、肺、乳腺、前列腺、卵巢癌、白血病和淋巴瘤中失调。ACTB 通常在大多数肿瘤细胞和组织中上调。ACTB 的异常表达和聚合以及由此导致的细胞骨架变化被揭示与癌症的侵袭和转移有关。本综述探讨了相关机制，整合了目前的认识，并为 ACTB 在肿瘤中的作用的未来研究提供了建议。
