Department of Laboratory Medicine and Pathology, St. Michael's Hospital, 30 Bond Street, Toronto, ON, Canada.
Anticancer Res. 2013 Jan;33(1):119-22.
Pituitary tumor-transforming gene (PTTG1) has been implicated in several oncogenic processes. The aim of this study was to determine PTTG expression in brain tumors.
We investigated 88 benign and malignant brain tumors. PTTG immunoexpression was evaluated using a scale of 0 to 3. PTTG immunoexpression was nuclear and cytoplasmic in most tumors, except for medulloblastomas and hemangiopericytomas. Expression was highest in medulloblastomas. Higher grade gliomas including glioblastoma multiforme (GBM) IV and astrocytoma III had the highest level of PTTG expression, whereas low-grade gliomas had the lowest levels of PTTG expression. Hemangiopericytomas had the lowest levels of PTTG immunoreactivity, with meningiomas and schwannomas exhibiting similarly low PTTG levels. Nuclear PTTG immunoreactivity was higher than cytoplasmic in higher-grade tumors.
Our results indicate that PTTG immunoexpression is higher in aggressive brain tumors including medulloblastomas, GBM IV, and astrocytoma III, whereas in more benign tumors, PTTG immunoexpression is lower.
垂体肿瘤转化基因（PTTG1）参与了多种致癌过程。本研究旨在确定脑肿瘤中 PTTG 的表达情况。
我们研究了 88 例良性和恶性脑肿瘤。使用 0 到 3 的评分来评估 PTTG 免疫表达。大多数肿瘤的 PTTG 免疫表达为核浆型，除了髓母细胞瘤和血管外皮细胞瘤。髓母细胞瘤的表达最高。高级别胶质瘤包括胶质母细胞瘤 IV 级和星形细胞瘤 III 级具有最高水平的 PTTG 表达，而低级别胶质瘤具有最低水平的 PTTG 表达。血管外皮细胞瘤的 PTTG 免疫反应性最低，脑膜瘤和 schwannomas 表现出相似的低 PTTG 水平。核 PTTG 免疫反应性在高级别肿瘤中高于细胞质。
我们的结果表明，侵袭性脑肿瘤包括髓母细胞瘤、胶质母细胞瘤 IV 级和星形细胞瘤 III 级中 PTTG 免疫表达较高，而在更良性的肿瘤中，PTTG 免疫表达较低。
