分离酶通过基质金属蛋白酶促进胶质瘤细胞的迁移和侵袭。
Securin promotes migration and invasion via matrix metalloproteinases in glioma cells.
作者信息
Yan Haicheng, Wang Wei, Dou Changwu, Tian Fuming, Qi Songtao
机构信息
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Department of Oncology, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China.
出版信息
Oncol Lett. 2015 Jun;9(6):2895-2901. doi: 10.3892/ol.2015.3074. Epub 2015 Mar 26.
Abstract
Human securin, encoded by pituitary tumor transforming gene 1, is implicated in several oncogenic processes in the pathogenesis of brain tumors, including glioma. The aim of the present study was to examine the effect of securin on the migration and invasion of glioma cells. The results revealed that the overexpression of securin in glioma LN-229 cells significantly increased the invasion and transmigration abilities. By contrast, these abilities were significantly reduced by the downregulation of securin in glioma U373 cells. Furthermore, the results demonstrated that securin overexpression and downregulation significantly increased and decreased the levels of matrix metalloproteinase 2 and 9, respectively. These findings indicate a promotive role for securin in glioma migration and invasion, which may involve the action of matrix metalloproteinases.
摘要
垂体肿瘤转化基因1编码的人类securin在包括神经胶质瘤在内的脑肿瘤发病机制的多个致癌过程中发挥作用。本研究的目的是检测securin对神经胶质瘤细胞迁移和侵袭的影响。结果显示，在神经胶质瘤LN-229细胞中过表达securin显著提高了侵袭和迁移能力。相比之下，在神经胶质瘤U373细胞中下调securin则显著降低了这些能力。此外，结果表明，securin的过表达和下调分别显著提高和降低了基质金属蛋白酶2和9的水平。这些发现表明securin在神经胶质瘤迁移和侵袭中起促进作用，这可能涉及基质金属蛋白酶的作用。
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