Department of Endocrinology, Hospital General Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, Barcelona, 08035. Spain.
Anticancer Res. 2013 Jan;33(1):337-40.
There is an increased incidence of secondary primary cancer (SPC) in patients with papillary thyroid carcinoma (PTC). The risk is stronger in the first year after the first malignancy (synchronous tumours). The aim of this study was to assess the prevalence of SPC in patients with PTC, and to analyse whether the timing of tumour presentation influenced the clinicopathological characteristics of PTC.
A total of 184 patients with PTC were included in the study.
There were 24 patients with SPC and nine with PTC and two other primary tumours (42 additional malignancies in total). Additional tumours were more prevalent in male and older patients. In 11 cases (33%), the two carcinomas were synchronous. PTCs from synchronous cases were significantly larger than those from non-synchronous cases.
Patients with PTC were at elevated risk for SPC. In one third of patients, both neoplasms were diagnosed within the same year. Male and older patients were more likely to have SPC.
患有甲状腺乳头状癌（PTC）的患者中，继发性原发性癌症（SPC）的发病率增加。在首次恶性肿瘤（同步肿瘤）后第一年的风险更大。本研究的目的是评估 PTC 患者中 SPC 的患病率，并分析肿瘤表现的时间是否会影响 PTC 的临床病理特征。
本研究共纳入 184 例 PTC 患者。
共有 24 例患者患有 SPC，9 例患者同时患有 PTC 和另外两种原发性肿瘤（共 42 种其他恶性肿瘤）。附加肿瘤在男性和老年患者中更为常见。在 11 例（33%）中，两种癌是同步发生的。同步病例的 PTC 明显大于非同步病例的 PTC。
患有 PTC 的患者发生 SPC 的风险增加。在三分之一的患者中，两种肿瘤均在同一年内被诊断出。男性和老年患者更易发生 SPC。
