Ben Thayer Maissa, Khanchel Fatma, Helal Imen, Chiboub Dorra, Ben Lazreg Khouloud, Hedhli Raweh, Ben Brahim Ehsen, Jouini Raja, Cheddli-Debbich Aschraf
Faculty of Medicine of Tunis Tunis El Manar University Tunis Tunisia.
Depatment of Pathology Habib Thameur's Hospital Tunis Tunisia.
Clin Case Rep. 2022 Aug 9;10(8):e6246. doi: 10.1002/ccr3.6246. eCollection 2022 Aug.
Papillary thyroid carcinoma is the most common type of thyroid cancer and accounts for almost 89.4% of all thyroid carcinomas. Hodgkin lymphoma is a heterogeneous group of neoplasms and represents 10% of lymphomas. These two cancers do not share the same risk factors. Some studies have reported the association of thyroid papillary carcinoma with lymphomas, mainly Hodgkin's lymphoma, treated with radiotherapy. However, to our knowledge less than 10 cases have illustrated synchronous papillary thyroid carcinoma and Hodgkin lymphoma with no history of radiotherapy. We present the case of a 49-year-old female patient, with no history of past exposure to radiation, who was incidentally diagnosed with Hodgkin lymphoma during the work up for papillary thyroid carcinoma. Our patient had total thyroïdectomy with cervical lymphadenectomy. The histopathologic examination concluded to a papillary thyroid carcinoma of classical variant. And the lymph node dissection enabled us to diagnose not only papillary thyroid carcinoma's lymph node metastasis, but also Hodgkin Lymphoma. This discovery of the Hodgkin lymphoma was totally incidental. The discovery of synchronous tumors in patients with papillary thyroid carcinoma has been reported in the literature. However, the diagnosis of Hodgkin through lymph node dissection for papillary thyroid carcinoma is extremely rare. This underlines the singularity and the importance of our case. The synchronous papillary thyroid carcinoma and Hodgkin lymphoma is a rare condition, which may pose significant diagnostic and treatment dilemmas. To date, there is no standardized approach due to lack of experience. The molecular mechanisms of this link are poorly understood and yet remain to be elucidated.
乳头状甲状腺癌是最常见的甲状腺癌类型，占所有甲状腺癌的近89.4%。霍奇金淋巴瘤是一组异质性肿瘤，占淋巴瘤的10%。这两种癌症没有相同的危险因素。一些研究报告了甲状腺乳头状癌与接受放疗的淋巴瘤，主要是霍奇金淋巴瘤之间的关联。然而，据我们所知，少于10例病例说明了无放疗史的同步性乳头状甲状腺癌和霍奇金淋巴瘤。我们报告一例49岁女性患者，既往无辐射暴露史，在对乳头状甲状腺癌进行检查时意外诊断为霍奇金淋巴瘤。我们的患者接受了全甲状腺切除术和颈部淋巴结清扫术。组织病理学检查结果为经典型乳头状甲状腺癌。淋巴结清扫不仅使我们能够诊断乳头状甲状腺癌的淋巴结转移，还能诊断霍奇金淋巴瘤。霍奇金淋巴瘤的发现完全是偶然的。文献中已报道了乳头状甲状腺癌患者中同步性肿瘤的发现。然而，通过对乳头状甲状腺癌进行淋巴结清扫诊断出霍奇金淋巴瘤极为罕见。这突出了我们病例的独特性和重要性。同步性乳头状甲状腺癌和霍奇金淋巴瘤是一种罕见情况，可能带来重大的诊断和治疗难题。由于缺乏经验，目前尚无标准化方法。这种关联的分子机制了解甚少，仍有待阐明。
