Wilkenfeld Ari J L, Frank Samuel A, McCarthy David C
Department of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA.
Neurologist. 2013 Jan;19(1):15-6. doi: 10.1097/NRL.0b013e31827aa7ab.
Botulinum toxin (BTX) has been used to treat muscle overactivity and can reduce pain from muscle spasm. There are no previous reports to our knowledge of using BTX to treat the pain from intractable focal motor seizures.
We present a case of chronic, focal, muscle pain, and spasm secondary to intractable focal motor seizures treated with BTX. The patient experienced significant relief in muscle pain despite continued seizures.
On the basis of the case presented, BTX may have a limited role in the treatment of pain from muscle spasm in intractable focal seizures. Further study is necessary to see if this use of BTX is generally applicable.
肉毒杆菌毒素（BTX）已被用于治疗肌肉过度活动，并可减轻肌肉痉挛引起的疼痛。据我们所知，以前没有关于使用BTX治疗顽固性局灶性运动性癫痫疼痛的报道。
我们报告一例用BTX治疗顽固性局灶性运动性癫痫继发的慢性、局灶性肌肉疼痛和痉挛的病例。尽管癫痫仍在发作，但患者的肌肉疼痛得到了显著缓解。
根据所呈现的病例，BTX在治疗顽固性局灶性癫痫的肌肉痉挛疼痛方面可能作用有限。有必要进一步研究以确定BTX的这种用途是否普遍适用。
