Grespi Francesca, Melino Gerry
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK.
Aging (Albany NY). 2012 Dec;4(12):923-31. doi: 10.18632/aging.100515.
P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival. Accordingly, p73 has been identified as key player in many age-related neurodegenerative diseases, such as Alzheimer's disease, neuroAIDS and Niemann-Pick type C disease. Here we investigate possible correlations of p73 with Parkinson disease. Tyrosine hydroxylase is a crucial player in Parkinson disease being the enzyme necessary for dopamine synthesis. In this work we show that levels of tyrosine hydroxylase can be influenced by p73. We also demonstrate that p73 can protect against tyrosine hydroxylase depletion in an in vitro model of Parkinson disease.
P73是p53转录因子家族的成员，在神经生物学中发挥着重要作用，影响大脑发育并控制神经元存活。因此，p73已被确定为许多与年龄相关的神经退行性疾病的关键因素，如阿尔茨海默病、神经艾滋病和尼曼-皮克C型病。在这里，我们研究p73与帕金森病之间可能的相关性。酪氨酸羟化酶是帕金森病中的关键因素，是多巴胺合成所必需的酶。在这项工作中，我们表明酪氨酸羟化酶的水平可受p73影响。我们还证明，在帕金森病的体外模型中，p73可以防止酪氨酸羟化酶的耗竭。
