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向临床局限性前列腺癌男性患者介绍治疗方案:主动监测/观察的可接受性。

Presenting treatment options to men with clinically localized prostate cancer: the acceptability of active surveillance/monitoring.

作者信息

Donovan Jenny L

机构信息

School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, UK.

出版信息

J Natl Cancer Inst Monogr. 2012 Dec;2012(45):191-6. doi: 10.1093/jncimonographs/lgs030.

Abstract

Presenting treatment options to men with localized prostate cancer is difficult because of the lack of definitive evidence and the range of treatment options available. Active surveillance and monitoring programs are now a recognized treatment option for men with low-risk localized prostate cancer, but many patients are not fully aware of the details of such programs, and most still opt for immediate radical (surgery or radiotherapy) treatment. The provision of high-quality information with decision aids has been shown to increase the acceptability of active surveillance/monitoring programs. This chapter outlines techniques for providing high-quality information about active surveillance/monitoring, based on the findings of a randomized controlled trial of treatments for localized prostate cancer. The ProtecT (Prostate testing for cancer and Treatment) trial has randomized over 1500 men between active monitoring, radical surgery, and radical radiotherapy by ensuring that information was tailored to men's existing knowledge and views. Care was taken with the content, order, and enthusiasm of the presentation of treatments by recruitment staff, and clinicians and other health professionals were supported to feel comfortable with being open about the uncertainties in the evidence and helped to rephrase terminology likely to be misinterpreted by patients. These techniques of information provision should be added to the use of decision aids to enable patients diagnosed with clinically localized prostate cancer in routine practice to reach well-informed and reasoned decisions about their treatment, including full consideration of active surveillance and monitoring programs.

摘要

由于缺乏确凿证据以及可用治疗方案的多样性,向患有局限性前列腺癌的男性介绍治疗选择颇具难度。主动监测计划现已成为低风险局限性前列腺癌男性患者公认的一种治疗选择,但许多患者并不完全了解此类计划的详情,且大多数患者仍选择立即进行根治性(手术或放疗)治疗。事实表明,提供带有决策辅助工具的高质量信息可提高主动监测计划的可接受性。本章基于一项局限性前列腺癌治疗随机对照试验的结果,概述了提供有关主动监测高质量信息的技巧。前列腺癌检测与治疗(ProtecT)试验通过确保信息根据男性现有的知识和观点进行量身定制,已将1500多名男性随机分配至主动监测、根治性手术和根治性放疗组。招募人员在介绍治疗方法时,会注意内容、顺序和热情程度,同时支持临床医生和其他卫生专业人员坦然面对证据中的不确定性,并帮助他们重新表述可能会被患者误解的术语。应将这些信息提供技巧与决策辅助工具结合使用,以使在常规医疗中被诊断为临床局限性前列腺癌的患者能够就其治疗做出明智且合理的决策,包括充分考虑主动监测计划。

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