肝毒性微囊藻毒素-RR 在富营养化湖泊（中国太湖）中常见鲤鱼体内的分布和积累及其谷胱甘肽/半胱氨酸代谢物的初步研究。
Preliminary study of the distribution and accumulation of GSH/Cys metabolites of hepatotoxic microcystins-RR in common carp from a lake with protracted cyanobacterial bloom (Lake Taihu, China).
机构信息
Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7th, Wuhan, 430072, People's Republic of China.
出版信息
Bull Environ Contam Toxicol. 2013 Mar;90(3):382-6. doi: 10.1007/s00128-012-0947-6. Epub 2012 Dec 28.
Tissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 μg g(-1) DW) was 4 times of that in liver (0.063 μg g(-1) DW). Ratios of MC-RR-Cys/MC-RR in liver/kidney reached as high as 5.3/39.8, respectively, meanwhile, kidney showed low accumulation of MC-RR and higher formation efficiency of MC-RR-Cys than liver (7.51× to liver), this suggested that MC-RR-Cys were significantly accumulated with the depletion of MC-RR, and it was selectively biotransformed to MC-RR-Cys in kidney for further excretion.
研究了太湖野生鱼类组织中谷胱甘肽和微囊藻毒素-RR 半胱氨酸 S-结合物的组织分布和季节动态。在组织中发现了高浓度的 MC-RR-Cys，肾脏（0.253μg/g DW）中的 MC-RR-Cys 平均值是肝脏（0.063μg/g DW）的 4 倍。肝脏/肾脏中 MC-RR-Cys/MC-RR 的比值分别高达 5.3/39.8，同时，肾脏对 MC-RR 的积累较低，MC-RR-Cys 的形成效率高于肝脏（是肝脏的 7.51 倍），这表明随着 MC-RR 的消耗，MC-RR-Cys 明显积累，并在肾脏中被选择性生物转化为 MC-RR-Cys 以进一步排泄。
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