Production and investigating of tablets containing furosemide and beta-cyclodextrin.

Furosemide is a very active drug with an excellent saluretic effect, but it dissolves in water only with difficulty. Furosemide products with beta-cyclodextrin (CD) have been made by five methods, and it has been established that most drugs are liberated most quickly from the kneaded product for the 12.72% combinations. The dissolution characteristics of furosemide are improved in tablets made from the kneaded product. By this means an essentially quicker effect can be achieved, a lower drug quantity is necessary for a similar effect, a smaller therapeutic risk in involved, and the technique is economical too.