苯并咪唑对炔基溴化物的亲核加成/钯催化的分子内 C-H 乙烯基化：苯并[4,5]咪唑并[2,1-a]异喹啉的合成。
Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines.
机构信息
Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin, 150040, P. R. China.
出版信息
J Org Chem. 2013 Feb 1;78(3):1242-8. doi: 10.1021/jo302471z. Epub 2013 Jan 7.
PMID:23272698
Abstract
An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation.
摘要
一种高效的“一锅法”合成苯并[4,5]咪唑并[2,1-a]异喹啉的方法已经被开发出来，该方法通过 2-芳基苯并咪唑与炔基溴化物的亲核加成，以及随后的钯催化的分子内 C-H 乙烯基化反应来实现。
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